The 巨型诅咒骷髅头 is a 困难模式, post-世纪之花 敌怪 found in the 地牢, most commonly in areas with Tiled or Slab Walls. It acts similarly to the 诅咒骷髅头 in flight pattern, except it is much larger and will occasionally shoot high-velocity blasts that pass through tiles.
It is immune to 着火了！, 毒液, 暗影焰, 中毒, and 诅咒地狱 减益s.
- It will not usually cast bolts through walls until it has passed into open space or been damaged by the player (Using weapons that can pass through walls, such as 爆裂藤蔓). After being damaged or going into open space, it can fire bolts even if inside walls.
- It will open its mouth prior to attacking, and its attack can be interrupted.
- 18.104.22.168：Can now drop its own respective banner.